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2026
2 Publications
iSpy-LIFE & EXPLORE 2026
Systematic Review

Human Antibody Responses to Group A Streptococcus Infection

UK Australia USA University of Bristol • MCRI Melbourne • Imperial College London • UC San Diego

Network Authors: Rachael Barr, Hannah Frost, Alice Halliday, Adam Finn, Victor Nizet, Shiranee Sriskandan, Joshua Osowicki & Anu Goenka

iSpy-LIFE 2026
Frontiers in Cellular and Infection Microbiology

T cells in Group A Streptococcus infection: protection or pathology?

UK The Gambia University of Bristol • University of Oxford • MRC Unit The Gambia at LSHTM

Network Authors: Liya Mathew, Mohammad Ali, Hermaleigh Townsley, Alice Halliday, Paul Klenerman, Thushan I. de Silva & Anu Goenka (on behalf of the iSpy-LIFE network)

2025
2 Publications
iSpy-LIFE & EXPLORE 2025
The Lancet Microbe

Establishing the lowest penicillin concentration to prevent pharyngitis due to Streptococcus pyogenes using a human challenge model (CHIPS)

Australia Fiji The Kids Research Institute Australia • Murdoch Children’s Research Institute • Fiji National University

Network Authors: Joshua Osowicki, Kristy Azzopardi, Joseph Kado, Alma Fulurija & Andrew C. Steer

iSpy-LIFE & EXPLORE 2025
Infection and Immunity

Acquisition of toxin-encoding lysogenic bacteriophage elements enhances the virulence of pandemic Streptococcus pyogenes M1UK

Canada Australia University of Western Ontario • The University of Queensland

Network Authors: Juan Manuel Díaz, Jasmine E. J. Wells, Aanchal Rishi, Mark J. Walker & John K. McCormick

Participating Network Institutions

Ongoing collaborative studies are underway across all partner hubs in both subnetworks
iSpy-LIFE Partner Institutions

Imperial College London • MRC Unit The Gambia at LSHTM • University of Bristol • University of Oxford • Amsterdam UMC • Lund University • University of Cape Town • University of Western Ontario • The Kids Research Institute Australia

iSpy-EXPLORE Partner Institutions

UC San Diego • La Jolla Institute for Immunology • Center for Human Systems Immunology (CHSI), Duke University • Murdoch Children’s Research Institute • The University of Queensland • The Kids Research Institute Australia • University of Auckland • Federal University of Minas Gerais • Fiji National University