iSpy-LIFE Hub
London, United Kingdom
Imperial College London
Investigators:
Shiranee Sriskandan, Tom Parks, Rebekah Bingham
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iSpy-Lifers × iSpy-Explorers
How Our Two Sub-Networks Work Together
Shared Samples & Cohorts
Immunological samples and curated S. pyogenes strains from school and household studies in London, The Gambia, South Africa, Australia, New Zealand, Fiji, and Brazil.
Shared Discovery Platforms
Cross-network access to high-density slides, phage libraries, systems serology, and epitope mapping.
Cross-Model Testing
Comparing natural immune findings from children and adults with responses in tonsil organoids, HLA-humanised models, human challenge models (), and candidate vaccines.
Correlates of Protection
Combining antibody and cellular datasets across all 19 hubs to identify safe, broadly protective vaccine antigens without autoimmune cross-reactivity.